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This reaction is catalyzed by long-chain fatty acyl-CoA synthetase.[5] LCFA-CoAs then can diffuse through the outer mitochondrial membrane where they are converted to acylcarnitine in a presence of carnitine by the enzyme carnitine palmitoyltransferase-1 (CPT-I)

Study Endpoints The primary endpoint of this meta-analysis was the proportion of patients with post-treatment ALT normalization

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