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Interestingly, such effects of sequence variation can spread across neighboring CpGs and thus contribute to the observed correlated nature of DNA methylation at neighboring CpGs (Shoemaker et al., 2010)

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In tobamovirus Rep protein, the consensus sequences (GXXXXGKT and DEAD box in the helicase domain, and GDD and SGXXXTXXXNT in polymerase domain) were also conserved, except the last amino acid Thr in GXXXXGKT has been substituted by Ser in both the viruses (Figure 4)

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