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4.2.1.2 Lutein and zeaxanthin Comhaire et al., conducted a study involving 30 subfertile men which were treated with 16 mg a day of astaxanthin, a carotenoid which is not transformed into vitamin A in humans, for 3 months and did not find any, significant enhancement in concentration, motility, morphology or volume in the 11 treated men compared with the 19 control patients [111]

Since it is suggested that p53, p16, p21 are directly related to the induction of senescence in chondrocytes (Ashraf et al., 2016), we thus used qRT-PCR and western blot analysis to examine their expression levels

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These mice have markedly reduced circulating IGF-1 levels (approximately 80% reduction), a slight reduction in body length while body mass was maintained (221, 304)