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Adversely affecting the brain, nicotine acts as a temporary antidepressant but sends smokers back to depressive spells

A study by UC San Diego showed that people aged 12 to 24 who used e-cigarettes were three times as likely to become daily cigarette smokers in the future There is also a growing body of evidence suggesting that e-cigarettes expose consumers to significant health harms, and that the tobacco industry is using them to capture a new generation of consumers, and create an image as an industry concerned by public health and wanting to reduce the harms created by decades of tobacco use

Handling missing data Five participants had missing outcome data for all outcomes, 626 participants had complete outcome data for the primary outcome and were analysed by original assigned groups (see Fig

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