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Clientized GST-S tail constructs containing either a Thr1273Asp or Thr1273Glu substitution showed 17-fold higher affinity for the -COPI subunit (a marker for the intact coatomer complex) than the wild-type GST-S tail construct (Fig

Nature 459 , 253256 (2009)

It classifies DILI as definite, highly probable, probable, possible, unlikely, or excluded. While the scale standardizes assessments, it should not be applied indiscriminately, as it does not establish causality and may lead to biased conclusions in poorly documented cases

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Retinal detachment and injury recovery Mechanism: Physical separation of retina from underlying RPE and choroid, cutting off blood supply and causing photoreceptor death within hours to days