Oxidative stress-mediated senescence and death of RPE and subsequent death of photoreceptors have been observed in age-related macular degeneration (AMD)
Left unchecked, they could cause oxidative damage to your cells
Possible long-term risks include: Gallstones or gallbladder inflammation, especially with rapid weight loss Pancreatitis, which is inflammation of the pancreas Kidney stress or acute kidney injury linked with dehydration from vomiting or diarrhoea Severe constipation or worsening digestive symptoms Delayed stomach emptying or gastroparesis-like symptoms Possible worsening of diabetic retinopathy in some people with type 2 diabetes, especially if blood sugar improves very quickly Increased heart rate in some people Allergic reactions, such as swelling, rash, itching, or breathing difficulty Mood changes or suicidal thoughts, which need immediate medical attention Loss of lean muscle mass if weight loss happens without enough protein and strength training Facial volume loss due to rapid weight loss, sometimes called Ozempic face, although this can happen with rapid weight loss from any cause Some GLP-1 medicines carry a warning related to thyroid C-cell tumours seen in animal studies
Separately, the US FDA concluded its review of a possible suicidal-ideation signal with GLP-1 receptor agonists and found no causal association
doi: 10.1007/s12094-020-02461-0
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