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His conclusion was that between 13 percent and 25 percent of cigarette consumers smuggle their smokes and that the central implication of this study is cross-border smuggling confounds many of the potential health and revenue gains from cigarette taxation. In 2012 the Centers for Disease Control wrote that smokers seem to be avoiding additional taxes while continuing to feed their nicotine habit

41 Pharmacogenetic trials have provided preliminary evidence that many of the same genes associated with nicotine dependence are modestly related to smoking cessation outcomes