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In many human cancer cells, the KEAP1-mediated regulation of NRF2 activity is abrogated, resulting in the persistent activation of NRF2

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Complementary Mechanisms When combined, these compounds create a multi-faceted approach to NO enhancement: Increased Substrate Availability - As described above, L-citrulline effectively raises plasma L-arginine levels, providing more raw material for nitric oxide synthase (NOS) enzymes to produce NO

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