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Studies examining multi-dose vial sterility have documented that preservative-containing diluents maintain vial integrity through the labeled use period (PMID: 6562087)

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There was increased tight junction protein expression (e.g., zonula occludens-1 (ZO-1)) and transepithelial resistance, which significantly mitigates leaky gut syndrome and stabilizes cellular junctions [18]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 29.Perovic D., Milavic M., Dokuzovic S., Krezic I., Gojkovic S., Vranes H., Bebek I., Bilic V., Somun N., Brizic I., et al