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Likewise, a study utilizing FDG-PET imaging of brain glucose metabolism revealed that PD is characterized by hypermetabolism in the putamen, pallidum, thalamic sensorimotor cortex, pons, and cerebellum, along with relative hypometabolism in the posterior temporal-parietal lobe, occipital lobe, and occasionally the frontal lobe, particularly in PD patients with cognitive impairment [36]

doi: 10.1007/s00018-021-03802-0 317 SpitzerS

Key TJ, Allen N, Appleby P, Overvad K, Tjonneland A, Miller A, Boeing H, Karalis D, Psaltopoulou T, Berrino F, Palli D, Panico S, Tumino R, Vineis P, Bueno-De-Mesquita HB, Kiemeney L, Peeters PH, Martinez C, Dorronsoro M, Gonzalez CA, Chirlaque MD, Quiros JR, Ardanaz E, Berglund G, Egevad L, Hallmans G, Stattin P, Bingham S, Day N, Gann P, Kaaks R, Ferrari P, Riboli E

Godwin LS, Castle JT, Kohli JS, Goff PS, Cairney CJ, Keith WN et al

The mechanism of cross-talk between mitochondria and microbes needs to be further investigated