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In addition to proliferation arrest, senescent cells also exhibit alterations to their morphology (increased flattening) and metabolism with the activation of the so-called senescence-associated secretory phenotype (SASP), whereby the cells secrete cytokines, chemokines and proteases, that have profound effects on neighbouring cells in the tumour microenvironment (TME) [26,27,28]

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Specifically, the FDA recently sent final rules regarding the ban to the White House Office of Management and Budget (OMB) to review

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