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After absorption, B12 is bound to transport proteins, 7580% to haptocorrin, which transports B12 in the blood, and 2025% to transcobalamin, which delivers B12 to the tissues, also referred to as active B12 or holo-transcobalamin

Moreover, the levels of 5-HT, DA, and NE in the cortex of mice were significantly elevated compared to those in the model group (Wei et al., 2022)

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Antioxidants 9:914

On the other hand, an increased distribution of MDM2 to the cell nucleus to interact with p53 may indirectly increase the expression of IGF-1R since lesser cytoplasmic MDM2 will be available to ubiquitinate and degrade the receptor