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43 Puff EC fluids were cytotoxic in the MTT and NRU assays, and IC 70 and IC 50 values were reached at fluid concentrations between 0.091.35 and 0.141.24%, respectively (Figure 2 and Table 1)

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Second, when the fitted models were used to predict RRs for non-users based on the ratio of biomarker levels for non-users to those smoking cigarettes from the ECIG studies providing data for these five biomarkers, the 95% CI for the predicted RR for non-users never included 1.0 and in many cases was similar to or greater than that for those smoking cigarettes

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