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In a record of 26,961 operations involving the use of general anesthesia, it was found that certain respiratory events, such as re-intubation, laryngospasm, bronchospasm, aspiration, and hypoventilation/hypoxemia occurred at an incidence of 5.5% in tobacco smokers and at an incidence of 3.1% in non-smokers, with the relative risk of these respiratory events being 1.8 in all smokers, 2.3 in young smokers (defined as those between 16 and 39 years of age) , and 6.3 in obese young smokers

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Vaping nicotine can intensify symptoms of depression and anxiety and increase stress levels, establishing a worrisome link to the growing youth mental health crisis, which was the subject of a Surgeon Generals Advisory issued in December 2021

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