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We observe five genome-wide significant loci, including previously unreported loci MAGI2/GNAI1 (rs2714700) and TENM2 (rs1862416), and extend loci reported for other smoking traits to nicotine dependence

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Humidor: Maintaining the right humidity levels is essential to preserve cigar freshness and flavor

Avoid deep inhalation: The less smoke you inhale, the lower the exposure to toxins