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The aortic root dilates in 50% of children and in 60 to 80% of adults and can cause aortic regurgitation, in which case a diastolic murmur may be heard over the aortic valve

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Am J Hum Genet 85:493502 Cloonan SM, Glass K, Laucho-Contreras ME, Bhashyam AR, Cervo M, Pabon MA, Konrad C, Polverino F, Siempos II, Perez E, Mizumura K, Ghosh MC, Parameswaran H, Williams NC, Rooney KT, Chen ZH, Goldklang MP, Yuan GC, Moore SC, Demeo DL, Rouault TA, D'Armiento JM, Schon EA, Manfredi G, Quackenbush J, Mahmood A, Silverman EK, Owen CA, Choi AM (2016) Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice

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