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doi: 10.1056/NEJMoa1612917 41 HernandezAFGreenJBJanmohamedSD'AgostinoRBGrangerCBJonesNPet al

While body weight and composition can influence drug distribution, the half-life of these specific medications is not significantly altered by body weight

GLP-1 medications delay gastric emptying, which means food may remain in the stomach longer than expected despite standard fasting

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For T2DM patients at high-risk or established cardiovascular disease, heart failure and/or chronic kidney disease, glucose-lowering therapies with demonstrated cardiorenal benefit should be utilized where appropriate