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Nine criteria were used to assess the study quality: study design, risk of bias, inconsistency, indirectness, imprecision, publication bias, large effect, dose-response and no plausible confounding

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People with an addiction will feel a compelling need to use a drug (which can be alcohol, the nicotine in tobacco, a prescription drug or an illegal chemical such as cocaine or heroin), even when the user knows that doing so risks severe health or legal consequences