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These drugs mimic the action of the naturally occurring hormone GLP-1 (glucagon-like peptide-1) in the body

In the SUSTAIN clinical trials, semaglutide OW achieved superior glycemic control and weight loss compared with several other classes of anti-diabetes medications (ADMs) [14,15,16,17,18], including canagliflozin, an SGLT2i [19]

Weeks 13 through 16: 1.7 mg once weekly A significant jump that many people find effective as a maintenance dose

468 Specifically, these agents can attenuate the excitability of carotid body cells and diminish sympathetic activation, ultimately leading to a reduction in sympathetic responses

It also lowers the risk of major cardiovascular events such as stroke, heart attack, or death in adults with type 2 diabetes who also have heart disease, and lowers the risk of worsening kidney disease, kidney failure (end-stage kidney disease), and death due to cardiovascular disease in adults with type 2 diabetes who also have chronic kidney disease