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Chronic problems eventually yield to acclimation, rendering them relatively imperceptible

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Lead author Dr Maisem Laabei said: 'We expected some effects but we didn't anticipate smoke would affect drug-resistance to this degree

Unlike cigarette testing machines, which were calibrated to smoke the putative reduced-risk cigarettes in a standardised way, smokers compensated for the lower delivery of nicotine by taking more and deeper puffs per cigarette, smoking more and occluding the tiny ventilation holes on the filters with their fingers