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The most straightforward indication is expiration: any pen past its labeled expiration date should be discarded immediately, regardless of storage conditions or remaining medication volume

If it still doesnt dissolve, it could, in very rare instances, indicate a manufacturing issue

Confirm that the prescribing provider is board-certified and available for follow-up consultations

Managing Side Effects During Dose Increases Mild nausea, reduced appetite for favorite foods, and slight stomach discomfort are common during the first two weeks at each new dose level and typically fade as your body adjusts

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