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Heart Rate Elevation Mean resting heart rate increases by 2 to 4 bpm across the class, with some patients experiencing increases of 10 to 15 bpm

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* Correspondence: Zhiyuan Gao, [email protected] Tian, [email protected] Gao, [email protected] These authors have contributed equally to this work ORCID: Biao Gao, orcid.org/0000-0002-8871-1733 Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Heart-shaped lips often have a defined Cupids bow, a fuller center, and a lower lip that supports the overall shape