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In addition to the plethora of negative health effects caused by smoking (damaging arteries, impotence, tissue damage and blocking blood flow, among many others), the way smoking alters the brains chemistry is strikingly similar to what long-term alcohol abuse does

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Since cigarette smoke is known to modulate expression and activity of the maintenance methyltransferase DNMT1, actively dividing cells may be more susceptible to exposure-mediated defects in DNA methylation

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