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Similarly, exposure to methylglyoxal, a reactive dicarbonyl compound formed as a metabolic byproduct of glycolysis, has been shown to inhibit glycolysis, leading to a reduction in ATP and GSH concentrations

[24]Chung JY, Yu SD, et al

Moreover, the downregulated genes were involved primarily in infection, immune defense, and chemical signaling pathways (Fig

Any references to biological activity or potential mechanisms are derived solely from publicly available scientific literature and independent laboratory research contexts.

Administering hepsin to wild-type mice increases APAP tolerance and downregulates GJ expression Considering the potential clinical and medical applications, we evaluated a therapeutic strategy involving the administration of hepsin to wild-type adult mice and assessed its potential to mitigate APAP-induced liver injury