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The Haber-Weiss reaction involves the interaction of superoxide anions with hydrogen peroxide to produce hydroxyl radicals, while the Fenton reaction involves the reduction of hydrogen peroxide by ferrous iron, also generating hydroxyl radicals ( In addition to the aforementioned role through which A1AT acts with antioxidant action by increasing endogenous antioxidant enzymes, such as superoxide dismutase and catalase, it also exerts indirect mechanisms of protection against oxidative stress

Furthemore, an increased serotonin metabolism was demonstrated by diminished hypothalamic serotonin levels, lowered 5-hydroxytryptamine (5-HT)/tryptophan ratios and elevated 5-hydroxyindoleacetic acid/5-HT ratios, indicating dysregulated serotonergic system (Jia et al., 2024)

Free Rad Biol Med 19 :911918

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