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Any consideration of combination pharmacotherapy should involve shared decision-making, thorough discussion of risks and benefits, and close clinical follow-up

Some prescribers step the dose down rather than stopping outright, smoothing the return of appetite further, and evidence across the drug class suggests some weight regain is common after stopping, so agreeing in advance what would prompt a return to treatment removes the sting from that possibility

This also led its drug manufacturer, Novo Nordisk, to get a higher dose of the active ingredient semaglutide FDA-approved for weight management under the brand name Wegovy

Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome

Jason Wendel