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In humans with type 2 diabetes, islet mitochondria show large structural and biochemical changes
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However, at high concentrations, EGCG can exhibit pro-oxidant activity by inducing autoxidation, which generates hydroxyl radicals, hydrogen peroxide, and quinone intermediates, leading to cytotoxicity [131,132,133,134]
The immune response is primed to respond too aggressively and glutamate is primarily created and managed by our immune cells in the brain (microglia and astrocytes)