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Blood and/or urine cotinine tests may be ordered along with nicotine tests

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Physical activity affects reward, mood, and stress systems, among other things through changes in dopamine, serotonin, endorphins, and cortisol

But in fact, e-cigarettes produce an aerosol made up of tiny particles, which is different from a vapor. The e-liquid in most e-cigarettes contains nicotine and other substances that are addictive