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Christenson SA, Smith BM, Bafadhel M, Putcha N

A detailed evaluation of risk of bias is shown in Supplementary file Tables 2 and 3

Initial screening visit coding: Primary diagnosis: Z12.2 (Encounter for screening for malignant neoplasm of respiratory organs) Risk factors: F17.210 (current smoker) or Z87.891 (former smoker) This applies when NO nodules are found on the screening CT Screening that identifies a nodule: Primary diagnosis: R91.1 (if solitary nodule found) or R91.8 (if multiple nodules found) Secondary diagnosis: Z12.2 can still be included to show this was a screening encounter Risk factors: Include tobacco codes Subsequent surveillance imaging: Once a nodule is found, follow-up CTs are no longer "screening",they're diagnostic surveillance

Repeated exposure to these drugs of abuse, like nicotine, can alter the brains sensitivity to dopamine, which means one needs to consume more of the substance to feel the same effects

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