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Screening procedures included a physical examination (including oral cavity and oropharynx), vital signs, electrocardiogram, body mass index (BMI), clinical laboratory tests (hematology, serum chemistry, and urinalysis), serology, urine/saliva drug, urine/breath alcohol, cotinine screen, eCO, and pregnancy and FSH tests (for females as appropriate)

Researchers looked at the brain activity of a group of 85 heavy smokers (at least 10 cigarettes a day) using a method called fMRI, or functional magnetic resonance imaging

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