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The name reflects the historical context of its original characterization, although later research has expanded interest in DSIP beyond its initial classification

It triggers it centrally and peripherally through two distinct pathways

It activates lysyl oxidase, an enzyme that crosslinks collagen fibers to create strong scar tissue

IL-4 secreted by activated T cells has anti-angiogenic effects by inhibiting VEGF production in RA FLS, which helps relieve RA (88)

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