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Including fibroblasts or other mesenchymal cell populations in co-culture models could be crucial for studying smoke-induced effects, as these cells contribute to extracellular matrix remodeling, fibrosis, and epithelial-mesenchymal interactions, which are key processes in COPD and emphysema progression

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Cotinine, nicotines main breakdown product, may be used to determine if someone was exposed to nicotine

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