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But in the mid-1960s, researchers realized that while the filters made the cigarettes safer, (a term used loosely here and altogether a debatable claim) they also made them less satisfying because they filtered out the very things that smokers liked about smoking, like nicotine

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The oxidative stress marker Heme oxygenase-1 ( HMOX1 ) was strongly (more than 200-fold) upregulated after 24 h CSE exposure, although significance was not reached ( p = 0.13) (Fig