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In addition, excessive ROS production can lead to oxidative stress, which in turn affects sperm nuclear DNA, sperm mitochondrial respiratory activity 40 and endocrine function, leading to a variety of male reproductive system disorders, and consequently may lead to male infertility 41,42

Users commonly add it to tea or consume it directly by placing a pinch under the lower lip

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Although tobacco smoking has been proven to be an independent risk factor for gastric cancer [10, 32] evidence of its association with gastric cancer mortality remains limited

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