FIGURE 4 In addition to the aforementioned Figures, a Supplementary Figure also provided to refuse the role of solvent volume on neuropathic pain and motor dysfunction (Sham, sham received v2, CCI, CCI received v2) (Supplementary Figures 1, 2)
Studies demonstrate that exogenous MUFAs, such as exogenous oleic acid (OA) and palmitic oleic acid (POA), can replace PUFAs in the plasma membrane, reducing their sensitivity to oxidation, and thereby inhibiting ferroptosis caused by erastin and RSL3
Thus, the scarce human studies performed so far, regardless of all of the limitations in some of them (i.e., they lacked a large sample size, ethnic variation, and a sham control group), encompassed a wide range of investigations (i.e., ulcerative colitis [65], knee pain [263], and interstitial cystitis [264])
Science 340 (6136), 11001106
This has raised interest in the measurement of blood levels of LC and ACs to further understand how changes in mitochondrial macronutrient metabolism inform disease manifestation, progression, and severity