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Lorentz CU, Verbout NG, Wallisch M et al (2019) Contact activation inhibitor and factor XI antibody, AB023, produces safe, dose-dependent anticoagulation in a phase 1 first-in-human trial

They do not affect activity of the human enzyme IMPDH-II and show a non-competitive inhibition against both Hp-IMPDH substrates, IMP and NAD+

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Its sensitivity in detecting early cognitive changes, monitoring disease progression, and measuring treatment effects will make it indispensable for these trials