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Why Withdrawal Happens at All Nicotine is a highly addictive alkaloid that binds to nicotinic acetylcholine receptors (nAChRs) in the brain, triggering the release of dopamine the neurotransmitter associated with reward and pleasure [1]

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A single puff of tobacco smoke contains more than 4000 chemicals Most of these chemicals prevent the body from functioning the way it should Between 43-80 these chemicals cause cancer In the United States, more than 400,000 people die each year because of smoke-related illnesses