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Additionally, there is evidence of structural and functional loss of neurons in the suprachiasmatic nucleus (SCN) in this disease [40, 173]

This subpopulation of LARS B cells shows a preference for Leu metabolism, which can be induced by a Leu diet to promote mitochondrial NAD + production and oxidative metabolism and recruit NAD + -dependent protein deacetylase SIRTUIN-1 (SIRT1) to participate in the regulation of LARS B cells

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