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Six other studies that examined similar comparisons (sample size 80837) reported on smoking cessation and reduction but were all of very low certainty.29 35 One RCT that compared nicotine e-cigarettes to NRT ( n = 135) suggested there may be a large effect of e-cigarettes on cessation (161 more per 1000, 95% CI 15 more to 785 more

This would explain why, after just a few puffs on a tobacco cigarette, the nicotine receptors in the brain are filled to about 85%, and pretty much 100% full by the time you finish that cigarette