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Those dual roles are particularly useful for those who engage in intense physical exercise or activities, since the fatty-acid sourced energy itself fuels the performance, of course, but also helps preserve muscle glycogen levels (which prevents muscle damage, when the muscle tissues themselves get broken down to supply energy), and also inhibits the build-up of lactic acid (one of the primary causes of fatigue and delayed onset muscle soreness)

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CYP2E1 knockout mice showed resistance to the APAP high dose-associated hepatotoxicity, suggesting that CYP2E1 is the major cytochrome P450 enzyme participating in APAP metabolism and toxicity ( CYP2E1 in APAP toxicity, CYP enzymes, notably CYP2E1 , generate ROS and lipid peroxidation (Veith and Moorthy, 2018)

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doi: 10.1093/ibd/izy177 74 IwasakiAMedzhitovR