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Some SCFAs have been shown to beneficially affect host metabolism through secretion of gut hormones, such as glucagon-like peptide-1 (GLP1) and peptide YY, that affect appetite, reduce inflammation, and increase fat oxidation, as reviewed by Hernandez et al

The results showed improvements in total motility, pain VAS scores, and subjective and objective assessments of efficacy

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Tesamorelin acts primarily through the GHRH receptor in the anterior pituitary, while Ipamorelin selectively targets the ghrelin/growth hormone secretagogue receptor, known as GHS-R1a