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The mechanisms by which e-cigarettes cause these changes are not yet well understood, but they are likely related to the composition of the ingredients used in e-cigarette products and the harmful inhaled substances, such as carbonyls, volatile organic compounds, nicotine, trace metals, microbial toxins, and flavorings 33

Rothberg, M., Heloma, A., Svinhufvud, J., Khknen, E., and Reijula, K., Ann

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NLRP3 (NALP3) has a pyrin N-terminal domain which binds with the adaptor protein, ASC, to recruit pro-caspase-1 (p45), forming a multi-protein complex termed the inflammasome