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The 6J substrain has a deficiency of the mitochondrial enzyme nicotinamide nucleotide transhydrogenase (NNT), which transfers electron from NADH to NADP + thereby supporting the antioxidant glutathione peroxidase in mitochondria

Tirzepatide shows slightly greater average weight loss in clinical trials (15-22% vs 15% body weight), but individual response varies

For GLP-1 medications, clinical evidence shows that a significant proportion of patients do regain weight after stopping treatment, because the biological hunger signals that were being suppressed return

Comparison of pioglitazone vs glimepiride on progression of coronary atherosclerosis in patients with type 2 diabetes: the PERISCOPE randomized controlled trial

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