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So while acetylcholine normally provides the just the right amount of alertness when it b inds to its receptors, nicotine produces a much more intense response (increased alertness, pleasurable feelings) due to its higher concentrations at the acetylcholine receptors

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Meanwhile, the abstinence rate was 14% among patients who switched from CRNT to varenicline or who had their CRNT doses increased

10.1056/NEJMsa050467 [DOI] [PubMed] [Google Scholar] 4.Harris KK, Zopey M, Friedman TC

Symptoms and severity of withdrawal can depend on how long a person smoked, how much they smoked, and any additional health issues