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A 2011 systematic review and meta-analysis of nine randomized controlled trials including 19,810 women reported that combined supplementation with vitamins C (1,000 mg/day) and E (400 International Units/day) during pregnancy does not reduce the risk of preeclampsia in women with either low/moderate risk or high risk for this disorder (90)

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Faje A, Chunharojrith P, Nency J, Biller BM, Swearingen B, Klibanski A

A 2025 IRB-approved pilot study published in PubMed reported no adverse effects following intravenous administration of 20mg in 2 healthy adults, with monitored biomarkers (heart, liver, kidneys, thyroid, and blood glucose) returning normal results

Srivastava S, Basak U, Naghibi M, Vijayakumar V, Parihar R, Patel J, et al