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It is often associated with the feeling of slight irritation or a satisfying "kick" that some vapers seek, particularly when using e-liquids with nicotine

In the next step, the full text of articles was assessed, and 839 articles that did not meet the inclusion criteria were removed from the study based on the reasons given in the flowchart

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Preliminary study of buprenorphine and bupropion for opioiddependent smokers

[21] Additionally, e-cigarette liquids containing concentrated nicotine solutions present significant dangers, especially when accidentally ingested or absorbed through the skin , often affecting children most severely