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The genetic correlates relate primarily to variants in the genes coding for transporters controlling plasma UA, yet such presumed functional variants will also influence, through the same proteins, the transport of UA into the brain and subsequently into neurons and glia, as described below

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An important limitation of the available evidence is the relatively short duration of follow-up in many included trials

These terminal modifications confer resistance to aminopeptidase and carboxypeptidase degradation, with dual-modified peptides demonstrating substantially improved half-lives in biological matrices