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Although the analysis was limited by the extent of the documents available to the researchers, the authors say: "There is clear evidence that (British American Tobacco)'ss early interest in introducing (smokeless tobacco) in Europe was based on the potential for creating an alternative form of tobacco use in light of declining cigarette sales and social restrictions on smoking, with young people a key target." The authors note: "(the study's findings) indicate that the industry's rhetoric on harm reduction has been inconsistent with historical and recent documents and business actions

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According to published randomized controlled trials, short-term exposure causes higher plasma stresses or modifications in the vascular index