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Given the lag time between tobacco exposure and disease symptoms and diagnosis, identifying the association between e-cigarette use and sensitive biomarkers of subclinical cardiovascular injury is necessary for understanding the long-term effects of newer tobacco products such as e-cigarettes. Biomarkers Reveal Inflammation and Oxidative Stress Researchers used data from the Population Assessment of Tobacco and Health (PATH) Study, a nationally representative longitudinal cohort in the U.S

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They refer to this ratio as the 'margin of exposure' (MOE), which can be used to measure how likely a user is, on average, to unwittingly overdose on their drug of choice

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