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These detrimental effects are mediated by complex mechanisms, including direct hepatotoxicity, oxidative stress, immune dysregulation, oncogenic signaling, and systemic metabolic disturbances

Both functions utilized the MAST R package (v1.6.1) ( P 20 inflammatory cells on tile) as described previously ( p 0 , p 1 , p 2, p 3 for classes 0, 1, 2, and 3, from which the inflammation I score was computed as weighted sum, i.e

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